Process for the preparation of cabergoline

Details Process for the preparation of cabergoline Process for the preparation of cabergoline

2005-03-02

2010-12-28

Aulakh, Charanjit S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S067000

Reexamination Certificate

active

07858791

ABSTRACT:
A process for preparing cabergoline (I) from ergoline-8β-carboxylic acid ester (XIII) comprising the following steps. (XIII), (XVI), (XVII), (XVIII), (XIX), (I). The present case also relates to the intermediates (XVI), (XVII), (XVIII) and (XIX) as well as the polymorphic amorphous form of Cabergoline (I) and the production thereof.

REFERENCES:
patent: 5382669 (1995-01-01), Candiani et al.
Disposition and Urinary Metabolic Pattern of Cabergoline . . . by R. Battaglia et al. (Xenobiotica, 1993).

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