Process for the preparation of bisphosphonic acid

Details Process for the preparation of bisphosphonic acid Process for the preparation of bisphosphonic acid

2008-04-22

2008-04-22

Aulakh, Charanjit S. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C562S013000, C548S112000, C546S022000

Reexamination Certificate

active

11522908

ABSTRACT:
The present invention is to relate an improved process using anisole as solvent for the preparation of compound of formula (I) and its pharmaceutically acceptable salts thereof.wherein R represents —NR1R2, or a groupn=1, 2, 3, 4 and 5, where R1and R2may be same or different and independently represents hydrogen, or C1-6alkyl.

REFERENCES:
patent: 4407761 (1983-10-01), Blum et al.
patent: 4705651 (1987-11-01), Staibano
patent: 4922007 (1990-05-01), Kieczykowski et al.
patent: 5019651 (1991-05-01), Kieczykowski
patent: 5908959 (1999-06-01), Kubela et al.
patent: 2 130 794 (1973-01-01), None
Kieczykowski et al., “Preparation of (4-Amino-1-Hydroxybutylidene) bisphosphonic Acid Sodium Salt, MK-217 (Alendronate Sodium). An Improved Procedure for the Preparation of 1-Hydroxy-1,1-bisphosphonic Acids,” J. Org. Chem., 60, pp. 8310-8310, 1995.

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