Process for the preparation of binary indole alkaloids

Details Process for the preparation of binary indole alkaloids Process for the preparation of binary indole alkaloids

1993-05-03

1995-07-11

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D51904

Patent

active

054322790

ABSTRACT:
The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

REFERENCES:
patent: 5037977 (1991-08-01), Tan et al.
Chemical Abstracts 9th Collective Index, Chemical Substances, p. 40240 (1974).
Cullman, Chem Abs 82, 57996b (1974).
Grant & Hackh's Chemical Dictionary, 5th Et p. 30 (1987).
Encyclopedia of Technology, 3rd ed. Hampel, Ed (1990) p. 62.
Random House Dictionary, 2nd Edition (1988).
Hackh's Dictionary, 3rd Edition (1964) p. 44.

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