Process for the preparation of bicyclic peptide compounds

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07999068

ABSTRACT:
A new process for the preparation of bicyclic peptide compounds Formula (I) in high yields of high purity, useful as intermediates for preparing compounds with pharmacological activity, is described.

REFERENCES:
patent: WO 96/28467 (1996-09-01), None
Definition of derivative from http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=derivtive, pp. 1-5. Accessed Jul. 7, 2005.
Weisshoff H et al: “Structure determination and by-product profile of the NK2 receptor antagonist nepadutant, a bycyclic glycopeptid”; FEBS Letters, Elsevier Science Publishers, Amsterdam, NL, vol. 491, No. 3; Mar. 2, 2001, pp. 299-304.
Anisfeld S T et al: “A Convergent Approach to the Chemical Synthesis of Asparagine-Linked Glycopeptides” Journal of Organic Chemistry, vol. 55, No. 21, 1990, pp. 5560-5562, XP002288954, ISSN: 0022-3263.
Offer J et al: “On-Resin Solid-Phase Synthesis of Asparagine N-Linked Glycopeptides:Use of N-(2-Acetoxy-4-Methoxybenzyl)(AcHmb) Aspartyl Amide-Bond Protection to Prevent Unwanted Aspartimide Formation” Journal of the Chemical Society, Perkin Transactions 1, Chemical Society. Letchworth, GB, vol. 2, 1996, pp. 175-182, XP002055030; ISSN: 0300-922X.
Tuchalski, Gisbert et al: “Large scale synthesis of biologically active bicyclic hexapeptides”;Peptides 1996, Proceedings of the European Peptide Symposium, 24th, Edinburgh, Sep. 8-13, 1996 (1998), Meeting date 1996, 845-846. Editor(s) Ramage, Robert; Epton, Roger. Publisher: Mayflower Scientific, Kingswinford, UK., 1998; XP009028177.
Akaji, K et al: “Synthesis of MEN 11420, a glycosylated bicyclic peptide using a chloroimidazlinium coupling reagent”, Tetrahedron, Elsevier Science Publishers, Amsterdam, NL, vol. 57, No. 9, Feb. 25, 2001, pp. 1749-1755, XP004317634; ISSN: 0040-4020.
Caciagli V et al: “Large Scale Production of Peptides Using the Solid-Phase Continuous Flow Method. Preparative Synthesis of the Novel Tachykinin Antagonist MEN 10327” Journal of Peptide Science, John Wiley and Sons Ltd, GB, vol. 3, No. 3, May 1997, pp. 224-230, XP009028229; ISSN: 1075-2617.
International Search Report; Jul. 12, 2004; 7 pgs.; T.Vogt.
Davis Benjamin G: “Synthesis of glycoproteins.” Chemical Reviews, Feb. 2002, vol. 102, No. 2, Feb. 2002, pp. 579-601, XP002288955, ISSN: 0009-2665.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for the preparation of bicyclic peptide compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of bicyclic peptide compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of bicyclic peptide compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2671865

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.