Process for the preparation of .beta.-ketocarboxylic acid esters

Details Process for the preparation of .beta.-ketocarboxylic acid esters Process for the preparation of .beta.-ketocarboxylic acid esters

1992-03-11

1993-03-16

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 51, 560174, 554115, C07C 6974

Patent

active

051946718

ABSTRACT:
The invention relates to a process for the preparation of .beta.-ketocarboxylic acid esters of the general formula ##STR1## in which R.sup.1 is an alkyl radical having 1 to 4 C atoms, R.sup.2 is an alkyl radical or alkenyl radical having 2 to 15 C atoms or a phenyl radical and R.sup.3 is hydrogen or an alkyl or alkenyl radical having 1 to 6 C atoms, characterized in that acetocarboxylic acid esters of the general formula ##STR2## in which R.sup.1 and R.sup.3 are as defined, are reacted with calcium hydroxide or calcium oxide in the presence of an organic solvent and in the absence of water, the calcium chelate complexes formed are acylated with carboxylic acid chloride and the products are then cleaved with aqueous ammonium salt solution to form the .beta.-ketocarboxylic acid esters of formula (I).
The .beta.-ketocarboxylic acid esters readily accessible by the process according to the invention can be used as important intermediates in the synthesis of pharmaceutically active ingredients or plant protection agents.

REFERENCES:
patent: 2661374 (1953-12-01), Schechter
patent: 2948747 (1960-08-01), Karbum
patent: 3142692 (1964-07-01), Maggiulli
patent: 3565928 (1971-02-01), Hagarty
Harper, J. Chem. Soc., pp. 892-895 (1946).

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