Process for the preparation of .beta.-hydroxyketones

Details Process for the preparation of .beta.-hydroxyketones Process for the preparation of .beta.-hydroxyketones

1989-03-13

1990-02-06

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568361, 568322, C07C 4556

Patent

active

048989886

ABSTRACT:
A process for the preparation of .beta.-hydroxyketones comprising the catalytic hydrogenolysis of an aqueous solution of isoxazolines having the formula ##STR1## in a fixed bed reactor containing a transition metal catalyst at a temperature between 20.degree. to 150.degree. C. and a pressure from about 0 to 150 psig; wherein R.sub.1 and R.sub.2 are independently selected from hydrogen, alkyl, cycloalkyl or aromatic group and wherein the aqueous solution of isoxazolines is substantially free of acids or buffers.

REFERENCES:
patent: 3742063 (1973-06-01), Hagemeyer, Jr. et al.
patent: 3819714 (1974-06-01), Bluestone et al.
patent: 4226810 (1980-10-01), Redaelli et al.
patent: 4340764 (1982-07-01), Milner
patent: 4513150 (1985-04-01), Fischer et al.
Curran, J.A.C.S., vol. 104, pp. 4024-4026 (1982).
Martin et al., Tetrahedron Letters, vol. 24, pp. 1337-1344 (1983).
Kozikowski et al., Chem. Abst., vol. 97, #216,0572 (1982).
"Reduction of .DELTA..sup.2 -Isoxazolines. 3..sup.1 Raney-Nickel Catalyzed Formation of .beta.-Hydroxy Ketones"-Curran--Am. Chem. Soc., 1983, 105, 5826-5833.

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