Process for the preparation of benzothiazepines by cyclization w

Details Process for the preparation of benzothiazepines by cyclization w Process for the preparation of benzothiazepines by cyclization w

1992-05-13

1993-06-29

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D28102

Patent

active

052236129

ABSTRACT:
Process for the preparation of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H) -one of formula ##STR1## by direct cyclization of the compound of the formula ##STR2## with a catalytic amount of phosphonic acid.

REFERENCES:
patent: 5128469 (1992-07-01), Nishimoto et al.
H. Wissmann et al "New Peptide Synthesis", Angewandte Chemie International Edition In English, vol. 19, No. 2, (1980) pp. 133-134.
The Merck Index An Encyclopedia of Chemicals, Drugs, and Biologicals, 11th Ed. (1989), Abstract No. 3188.
Blackburn, et al "The Dealkylation of Phosphate and Phosphonate Esters By Iodotrimethylsilane: A Mild and Selective Procedure". J.C.S. Perkin I, (1980) pp. 1150-1153.
Chemical Abstracts, vol. 99, (1983), p. 577, Abstract No. 99:53972u.
Chemical Abstracts, vol. 106, (1987) p. 437, Abstract No. 106:4672a.

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