Process for the preparation of benzimidazolones

Details Process for the preparation of benzimidazolones Process for the preparation of benzimidazolones

1989-11-24

1991-03-26

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20934

Patent

active

050030795

ABSTRACT:
Process for the preparation of benzimidazolones of the formula (1) ##STR1## in which R.sub.1 and R.sub.2 are identical or different and denote hydrogen or halogen atoms, or alkyl(C.sub.1 -C.sub.4), alkoxy(c.sub.1 -C.sub.4), trifluoromethyl, phenyl, phenoxy or nitro groups, by reacting o-phenylenediamines of the formula (2) ##STR2## in which R.sub.1 and R.sub.2 have the meaning given, with phosgene in water in the presence of an alkali metal base or alkaline earth metal base or a salt of an alkali metal hydroxide or alkaline earth metal hydroxide and a weakly inorganic or organic acid or a mixture of such salts or a suitable buffer system, at a pH of about 6 to about 12, and at a temperature of about 20.degree. to 100.degree. C.

REFERENCES:
patent: 2933503 (1960-04-01), Clark et al.
patent: 4269989 (1981-05-01), Heise et al.
patent: 4288442 (1981-09-01), Friebe et al.
patent: 4374250 (1983-02-01), Hirashima et al.
Gadekar, S. M., J. Org. Chem., 27:1383-1386, (1962).
Schnabel, W. J. et al., J. Org. Chem., 34:1162-1165, (1969).

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