Process for the preparation of benazepril

Details Process for the preparation of benazepril Process for the preparation of benazepril

2005-07-19

2005-07-19

Wilson, James O. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

06919450

ABSTRACT:
The present invention relates to an improved process for the preparation of trifluoromethanesulfonic ester of ethyl (R)-2-hydroxy-4-phenylbutyrate, referred to here as triflate in structural Formula I, and to the use of this compound as intermediate for the preparation of ACE (Angiotensin Converting Enzyme) inhibitor, benazepril.

REFERENCES:
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patent: 0 072 352 (1982-08-01), None
Urbach & Henning, “A Favourable Diastereoselective Synthesis of N- (1-S-Ethoxycarbonyl-3-Phenylpropyl) -S-Alanine”,Tetrahedron Letters, 25(11): 1143-1146 (1984).
Peter J. Stang et al., “Single-Step Improved Synthesis of Primary and Other Vinyl Trifluoromethanesulfonates”, Synthesis, 283-284 (1980).
A. Garcia Martinez et al, “Sterically Hindered Bases. Synthesis of 2,4,6-Trisubstituted Pyrimidines”, Synthesis, 881-882 (Oct. 1990).

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