Process for the preparation of backbone cyclic peptides

Details Process for the preparation of backbone cyclic peptides Process for the preparation of backbone cyclic peptides

1995-05-18

1998-03-03

Robinson, Douglas W.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

525 5411, 530333, 530334, 530338, C07K 100, C07K 102, C07K 104, C07K 512

Patent

active

057235759

ABSTRACT:
Biologically active, backbone-cyclized peptides of the formula: ##STR1## amino acid residue, n or e is an integer of 1-10, m or d is 0 or an integer of 1-10, R is a naturally occurring or synthetic amino acid side-chain, E is a hydroxyl moiety or a carboxyl protecting group of a blocking group, optionally covalently attached to an insoluble polymeric support, and the circled line designates a spacer group of ##STR2## for formula I wherein M is --S--S--, --CO--NH-- or --S-- and p and q each is an integer of 2-10, or

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