Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-06-26
2007-06-26
Peselev, Elli (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S018500
Reexamination Certificate
active
11166250
ABSTRACT:
The present invention relates to an improved, cost effective and easy process for the preparation of azithromycin monohydrate isopropanol clathrate. The process provides a one-step method of preparing azithromycin monohydrate isopropanol clathrate directly from 9-deoxo-9a-aza-9a-homoerythromycin A. The process comprises at least partial dissolution and/or suspension of 9-deoxo-9a-aza-9a homoerythromycin A in isopropanol to form a mixture, adding methylating solution to the said mixture, refluxing or heating said mixture to form a reaction mixture, adding alkaline solution to the reaction mixture to adjust pH from about 10 to about 11 and isolating pure azithromycin monohydrate isopropanol clathrate. The process helps in reducing the total time of preparation, total utility cost for the production and also helps to avoid handling loss.
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Dunn et al., “Azithromycin, A Review of its Pharmacological Properties and Use as 3-day Therapy in Respiratory Tract Infections”,DrugsMar. 1996 pp. 483-505.
Kansal Vinod Kumar
Mistry Dhiren Natavarlal
Soni Kamlesh Sanmukhubhia
Thorat Mahadeo Maroti
Alembic Limited
Peselev Elli
Westerman, Hattori, Daniels & Adrian , LLP.
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