Process for the preparation of aryl-pyrido(1,4) benzodiazepines

Details Process for the preparation of aryl-pyrido(1,4) benzodiazepines Process for the preparation of aryl-pyrido(1,4) benzodiazepines

1987-04-13

1988-06-07

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546308, 540495, C07D47104

Patent

active

047497882

ABSTRACT:
A process is described wherein pyrido[1,4]benzodiazepines having the formula: ##STR1## wherein Q is NR.sup.1 R.sup.2 or ##STR2## are prepared from unsubstituted pyridobenzodiazepinones by alkylation reaction with halo-alkyl-Q followed by acylation of the other nitrogen; breaking the ring with an aryl Grignard reagent and recyclizing to add the aryl radical and form the azepine ring. Novel intermediates are thereby disclosed.

REFERENCES:
patent: 4447361 (1984-05-01), Taylor
patent: 4480100 (1984-10-01), Lo et al.
patent: 4560510 (1985-12-01), Lo et al.

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