Process for the preparation of aromatic methoxycarboxylic acid m

Details Process for the preparation of aromatic methoxycarboxylic acid m Process for the preparation of aromatic methoxycarboxylic acid m

1997-01-17

1998-06-09

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 56, C07C 6976

Patent

active

057636419

ABSTRACT:
In a process, improved in respect of yield, purity and simple procedure, for the preparation of aromatic methoxycarboxylic acid methyl esters by methylation of the corresponding aromatic hydroxycarboxylic acids with dimethyl sulfate in the presence of water and a base, a procedure is followed in which the water, base and aromatic hydroxycarboxylic acid are initially introduced into the reaction vessel, 1 to 2.5 times the molar amount of dimethyl sulfate (based on the methylatable hydroxyl and carboxyl groups) is metered in and, during this procedure, the pH of the reaction mixture is controlled by addition of an aqueous base in finely divided form.

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F. Dallacker, et al., Darstellung von Derivaten des Trimethoxybenzols, Monatshefte for Chemie, Bd. 91, pp. 1077-1088, (1960).
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H. Wieland, Die Oxydation des p-Anisidins und Dimethyl-p-anisidins, Ber. Dt. Chem. Ges., 43, pp. 712-728, (1910).

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