Process for the preparation of antiulcer agents

Details Process for the preparation of antiulcer agents Process for the preparation of antiulcer agents

1993-02-22

1995-02-21

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546256, 546118, 544 582, C07D40112

Patent

active

053917529

ABSTRACT:
Anti-ulcer agents having a methylsulfinyl bridge between a substituted pyridine moiety and a substituted benzimidazole moiety are prepared by oxidizing the corresponding compounds, having a methylthio bridge, with magnesium monoperoxyphthalate in a suitable solvent. The reaction may be run in an aromatic hydrocarbon solvent, wherein the product may crystallize out of the reaction solution and may be directly isolated by filtration.

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V. Meladinis et al., Zeitsch Fur Naturforsch. Sec. B-A, 44, 1453 (1989).

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