Process for the preparation of anthelmintive bioconversion produ

Details Process for the preparation of anthelmintive bioconversion produ Process for the preparation of anthelmintive bioconversion produ

1991-02-04

1992-06-09

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435 75, 435 76, 514 30, 536 71, C12P 1718, C12P 1958, C12R 1465

Patent

active

051206463

ABSTRACT:
There are disclosed new compounds with significant antiparasitic activity which are prepared by fermenting 13-epi-ivermectin aglycone in a novel microorganism identified as Streptomyces avermitilis MA-5542. The 13-epi-ivermectin aglycone compounds are modified by the microorganism by methylation at the 5-hydroxy position and the addition of an .alpha.-L-oleandrose at the 13-position hydroxy. The compounds are significant antiparasitic and anthelmintic agents and compositions for that use are also disclosed.

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patent: 4310519 (1982-01-01), Albers-Schonberg et al.
patent: 4806527 (1989-02-01), Christensen et al.
patent: 4873224 (1989-10-01), Linn et al.
patent: 4895837 (1990-01-01), Mrozik et al.
patent: 4897383 (1990-01-01), Sinclair
patent: 4906619 (1990-03-01), Eskola et al.

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