Process for the preparation of an organ specific antibodies labe

Details Process for the preparation of an organ specific antibodies labe Process for the preparation of an organ specific antibodies labe

1998-09-01

2000-07-18

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 169, 534 14, A61K 5110, C07F 500

Patent

active

06090366&

ABSTRACT:
A process for the preparation of an organ-specific substance labeled with technetium-99m
The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which no unwanted Tc-99m compounds are bound to the antibody. This is achieved by using the complexing agent required for the reducing agent in an amount which is stoichiometric relative to the reducing agent.

REFERENCES:
patent: 3987157 (1976-10-01), Molinski et al.
patent: 5116596 (1992-05-01), Bremer et al.
patent: 5164175 (1992-11-01), Bremer et al.
patent: 5175343 (1992-12-01), Fritzberg et al.
patent: 5723102 (1998-03-01), Bremer et al.

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