Process for the preparation of an optically pure aminoalcohol

Details Process for the preparation of an optically pure aminoalcohol Process for the preparation of an optically pure aminoalcohol

1996-02-07

1998-07-14

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25519

Patent

active

057806667

ABSTRACT:
A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (I) by reaction of 3,4-dichlorophenylacetic acid (II) with an alkali metal halogenoacetate, treatment of the 3-cyano-3-(3,4-dichlorophenyl)propionic acid (III) with D-(-)-N-methylglucamine, with second-order asymmetric conversion, hydrolysis of the D-(-)-N-methylglucamine salt of (-)-3-cyano-3-(3,4-dichlorophenyl,)propionic acid and enantioconservative reduction of the resulting levorotatory cyanoacid with a borane.

REFERENCES:
Cheng, C.Y. et al, Zhonghua Yaoxue Zazhi, 1992, 44(1),pp. 45-50.

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