Process for the preparation of an optically pure aminoalcohol

Details Process for the preparation of an optically pure aminoalcohol Process for the preparation of an optically pure aminoalcohol

1994-08-24

1996-04-30

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549419, 558 52, 558369, 558406, 564184, 564355, 564356, C07D21158, C07C25330, C07C25541, C07C21300

Patent

active

055126804

ABSTRACT:
A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (I) by reaction of 3,4-dichlorophenylacetonitrile (II) with an alkali metal halogenoacetate, treatment of the 3-cyano-3-(3,4-dichlorophenyl)propionic acid (III) with D-(-)-N-methylglucamine, with second-order asymmetric conversion, hydrolysis of the D-(-)-N-methylglucamine salt of (-)-3-cyano-3-(3,4-dichlorophenyl)propionic acid and enantioconservative reduction of the resulting levorotatory cyanoacid with a borane.

REFERENCES:
patent: 5236921 (1993-08-01), Emonds-Ai et al.
patent: 5317020 (1994-05-01), Emonds-Alt et al.
C.A.; Bastian et. al., 78(1973), 78: 159422w.

Affiliated with

Also associated with

Rating

Process for the preparation of an optically pure aminoalcohol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of an optically pure aminoalcohol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of an optically pure aminoalcohol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-629906