Process for the preparation of an intermediate of diltiazem

Details Process for the preparation of an intermediate of diltiazem Process for the preparation of an intermediate of diltiazem

1990-11-15

1992-04-07

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D28110

Patent

active

051029995

ABSTRACT:
A process for the preparation of intermediates useful for the synthesis of Diltiazem consisting in the racemization of (--)-cis-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H )-one is described.

REFERENCES:
patent: 3562257 (1971-02-01), Kugita et al.
patent: 4416819 (1983-11-01), Nagao et al.
patent: 4420628 (1983-12-01), Inoue et al.
patent: 4533748 (1985-08-01), Manghisi et al.
Chemical Abstracts 99:70782z (1983).
Chemical Abstracts 100:174862f (1984).
Chemical Abstracts 101:211188j (1984).
Chemical Abstracts 101:38486e.
Chemical Abstracts 102:62286f (1985).
Chemical Abstracts 103:87918x.

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