Process for the preparation of an indoline carboxylic acid

Details Process for the preparation of an indoline carboxylic acid Process for the preparation of an indoline carboxylic acid

1984-10-26

1986-06-17

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544342, 544343, 544344, C07D20912

Patent

active

045957665

ABSTRACT:
The invention relates to a novel process for the preparation of the optically pure 2S- or 2R-indolinecarboxylic acid of the formula ##STR1## and salts thereof. The process comprises forming the heterocyclic 5-membered ring in formula I from an open chain precursor by diastereoselective cyclization.

REFERENCES:
patent: 4374847 (1983-02-01), Greenfield
patent: 4485241 (1984-11-01), Schouten
patent: 4520205 (1985-05-01), Buzby et al.
A. Padwa (Editor), Organic Photochemistry, vol. 6, (1983), pp. 16, 17, 26, 32 and 36, Dekker Inc. NY.
Schultz et al., Synthesis of Functionalized Indolines, Tetrahedron 36, 1757 (1980).
Bycroft et al., Asymmetric Synthesis of .alpha.-Amino Acids, JCS Chem. Comm. 1975, 988.
Stanton et al., J. Med. Chem. 26, 1267 (1983), Bicyclic Amino Acid Derivatives.
Yoshimura et al., Bull. Chem. Soc. Japan 46, 2850 (1973) Piperazinediones.

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