Process for the preparation of an indole-3-acetohydroxamic acid

Details Process for the preparation of an indole-3-acetohydroxamic acid Process for the preparation of an indole-3-acetohydroxamic acid

1978-02-23

1980-01-29

Hollrah, Glennon H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032613A, C07D20912

Patent

active

041861337

ABSTRACT:
A process for the preparation of indole-3-acetohydroxamic acids having the formula: ##STR1## wherein R is a hydrogen atom or a p-chlorobenzoyl, benzyl or an allyl radical, in which the corresponding 2-methyl-5-methoxyindole-3-acetaldehyde is reacted with benzenesulfohydroxylamine in the presence of aqueous sodium hydroxide at from 0.degree. C. to 4.degree. C. at a pH less than 8, to form the sodium salt of the required acid. The required acid is liberated by the addition of hydrochloric acid and precipitated by the addition of water. The required acid in which R is a hydrogen atom may alternatively be prepared by debenzoylation of the acid in which R is the p-chlorobenzoyl radical.

REFERENCES:
patent: 3624103 (1971-11-01), De Martiis et al.
Smith, "The Chemistry of Open Chain Organic Nitrogen Compounds", vol. II, p. 90, (1966).

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