Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2004-10-28
2009-06-02
Swarts, Rodney P. (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023700, C536S024100, C536S024200, C536S024300, C536S024320, C424S009100, C424S009200, C424S093100, C424S093200, C424S093400
Reexamination Certificate
active
07541447
ABSTRACT:
ABrucellabacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live vaccine for immunization, prophylaxis or treatment of brucellosis comprises such a bacterium, either lyophilized or in a pharmaceutical vehicle. Nucleotide sequence fragments having the aforementioned deletion are disclosed, with methods for making them.
REFERENCES:
patent: 5718903 (1998-02-01), Adams et al.
Comerci et al; Vector Development for the Expression of Foreign Proteins in the Vaccine StrainBrucella abortusS19; Infection and Immunity; Aug. 1998; pp. 3862-3866; vol. 66, No. 8; American Society for Microbiology.
Cornish-Bowden, A; Nomenclature for Incompletely Specified Bases in Nucleic Acid Sequences: Recommendations 1984; Nucleic Acid Research; 1985; pp. 3021-3030;vol. 13-No. 9; IRL Press Limited; Oxford, England.
Comerci Diego José
Del Vecchio Vito G.
Ugalde Juan Esteban
Ugalde Rodolfo Augusto
Elman Gerry J.
Elman Technology Law P.C.
Swarts Rodney P.
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