Process for the preparation of an immunoglobulin which can be ad

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 858, 424101, A61K 39395, C07K 1506, C07K 1514

Patent

active

048809136

ABSTRACT:
The invention relates to a process for the preparation of an immunoglobulin which has no side effects, is stable on storage in liquid form and can be administered intravenously and which has a monomer content above 97%, in which euglobulins and other impurities are removed from a previously purified immunoglobulin solution by precipitation and adsorption on an ion exchanger, the immunoglobulin is stabilized by acid and heat treatment and is further purified by another ion exchanger treatment, and aggregated proteins are removed by precipitation with low molecular weight PEG. The solution is converted by ultra- and diafiltration into a form which can be used.

REFERENCES:
patent: 3429867 (1969-02-01), Bozicevich
patent: 3607857 (1971-09-01), Nelson
patent: 3664994 (1972-05-01), Perper
patent: 3869436 (1975-03-01), Falksveden
patent: 4124576 (1978-11-01), Coval
patent: 4136094 (1979-01-01), Condie
patent: 4165370 (1979-08-01), Coval
patent: 4276283 (1981-06-01), Eibl et al.
patent: 4318902 (1982-03-01), Stephan
patent: 4351710 (1982-09-01), Jain
patent: 4371520 (1983-02-01), Llemura et al.
patent: 4379086 (1983-04-01), Kimura et al.
patent: 4434093 (1984-02-01), Zolton et al.
patent: 4482483 (1984-11-01), Curry et al.
patent: 4762714 (1988-08-01), Mitra et al.
Skoog, Experientia 36 (1980), pp. 1157-1158 Chemical Abstracts 94:127193m (1981).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for the preparation of an immunoglobulin which can be ad does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of an immunoglobulin which can be ad, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of an immunoglobulin which can be ad will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1853775

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.