Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-12-02
1989-11-14
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
424 858, 424101, A61K 39395, C07K 1506, C07K 1514
Patent
active
048809136
ABSTRACT:
The invention relates to a process for the preparation of an immunoglobulin which has no side effects, is stable on storage in liquid form and can be administered intravenously and which has a monomer content above 97%, in which euglobulins and other impurities are removed from a previously purified immunoglobulin solution by precipitation and adsorption on an ion exchanger, the immunoglobulin is stabilized by acid and heat treatment and is further purified by another ion exchanger treatment, and aggregated proteins are removed by precipitation with low molecular weight PEG. The solution is converted by ultra- and diafiltration into a form which can be used.
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Skoog, Experientia 36 (1980), pp. 1157-1158 Chemical Abstracts 94:127193m (1981).
Conrad Werner
Doleschel Walter
Doleschel Walter N.
Schain Howard E.
Schwab & Co. Ges.m.b.H.
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