Process for the preparation of an asymmetric compound using a me

Details Process for the preparation of an asymmetric compound using a me Process for the preparation of an asymmetric compound using a me

1998-09-08

2000-07-18

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

568632, 568735, C07C25500, C07C 4100, C07C 3914

Patent

active

060909692

ABSTRACT:
A process for producing an asymmetric compound using a metal complex containing no rare earth metal element is disclosed. The process affords an optically active compound having high optical purity. Optically active binaphthol having the chemical formula and lithium aluminum hydride are reacted, or the optically active binaphthol, a dialkyl aluminum hydride, and a base containing an alkali metal (or a base containing alkaline earth metal) are reacted to prepare a metal complex comprising optically active binaphthol, aluminum, and alkali metal (or alkaline earth metal). This metal complex can be used as a catalyst to perform an asymmetric Michael reaction, an asymmetric phosphonylation reaction, or the like, to obtain, in a high yield, an asymmetric compound having high optical purity.

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Noyori et al., "Rational designing of efficient chiral reducing agents, highly enantioselective reduction of aromatic ketones by binaphthol-modified lithium aluminum hydride reagents, " J. Am. Chem. Soc., vol. 106, No. 22, Oct. 31 1984, pp. 6709-6716.

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