Process for the preparation of an aqueous dispersion of lipid ve

Details Process for the preparation of an aqueous dispersion of lipid ve Process for the preparation of an aqueous dispersion of lipid ve

1990-10-11

1993-08-10

Stoll, Robert L.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

252314, 424450, B01J 1312, B01J 1300, A61K 927

Patent

active

052346358

ABSTRACT:
To prepare an aqueous dispersion of lamellar lipid vesicles, at least one lipid is dissolved in at least one water-immiscible organic solvent; the organic phase thus obtained is added to an aqueous phase in such amounts that a dispersion of the oil-in-water type is obtained by vigorous stirring; the evaporation of the solvent(s) is carried out with vigorous stirring, the continuous phase of the dispersion always remaining the aqueous phase; and, should it become necessary, the dispersion is concentrated. The process can be carried out at low temperature (of the order of 35.degree. to 55.degree. C.), which makes it possible to encapsulate in the aqueous phase or to introduce into the vesicle sheets heat-sensitive active substances; the lipid concentration in the organic phase can reach up to 50% by weight.

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French Search Report of FR 89 13358.
Papahadjopoulos et al., Biochim. Biophys. Acta, vol. 135 (1967) pp. 639-652.
Chowhan et al., Biochim. Biophys. Acta, vol. 266 (1972) pp. 320-342.
Kim et al., Biochim. Biophys. Acta, vol. 728, pp. 339-348 (1983).

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