Process for the preparation of an .alpha.-amino acid amide

Details Process for the preparation of an .alpha.-amino acid amide Process for the preparation of an .alpha.-amino acid amide

1994-06-09

1996-04-09

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548496, 5483391, 564138, 564139, 564140, 564141, 530324, C07D20920, C07D23364, C07C23102

Patent

active

055063624

ABSTRACT:
An .alpha.-amino acid amide is prepared by reaction of an N.sup..alpha. -aryloxycarbonylamino acid with a compound containing a free amino group. This process makes it possible readily to prepare peptides, by direct reaction between the carboxyl group of the N.sup..alpha. -aryloxycarbonyl derivative of an amino acid and the free amino group of a second amino acid or of a peptide fragment, without requiring protection of the carboxyl function of the second amino acid or of the peptide fragment, nor a coupling agent nor a deprotection step.

REFERENCES:
patent: 5158962 (1992-10-01), Seitz et al.
Von Th. Wieland et al "Uber Peptidsynthesen, 32. Mitt." In: Die Makromolekulare Chemie, vol. 92, 1966, pp. 277-286.
R. A. Boissonnas et al. "Etude comparative de la scission de divers groupes de blocage de la fonction .alpha.-amino des acides amines". In: Helv. Chim. Acta, vol. 36, No. 4, 1953 pp. 875-886.

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