Process for the preparation of aminopyrimidines

Details Process for the preparation of aminopyrimidines Process for the preparation of aminopyrimidines

1987-12-14

1989-05-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544321, C07D23947

Patent

active

048311383

ABSTRACT:
Process for the preparation of aminopyrimidines
Pyrimidines of the formula I ##STR1## in which X and Y denote oxygen or sulfur and R.sup.1 and R.sup.2 denote C.sub.1 -C.sub.4 -alkyl, (C.sub.1 -C.sub.4 -alkoxy)-C.sub.1 -C.sub.2 -alkyl or halo-C.sub.1 -C.sub.4 -alkyl, are obtained through reaction of propanediimidates of the formula II ##STR2## or salts thereof with cyanurates of the formula R.sup.3 --O--CN in which R.sup.3 denotes C.sub.1 -C.sub.4 -alkyl, phenyl, phenyl which is substituted by 1, 2 or 3 radicals from the series comprising halogen, C.sub.1 -C.sub.4 -alkoxy and C.sub.1 -C.sub.4 -alkyl radicals, .alpha.- or .beta.-naphthyl or halo-C.sub.1 -C.sub.4 -alkyl, in an organic solvent which is inert under the reaction conditions. The one-step process permits efficient preparation of the compounds of the formula I, which can be used as intermediates for the preparation of herbicidal sulfonylureas.

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