Process for the preparation of amino acid-derived enatiomeric co

Details Process for the preparation of amino acid-derived enatiomeric co Process for the preparation of amino acid-derived enatiomeric co

1990-06-19

1992-08-04

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Esters having the thiocarboxylate group, -cx-, wherein the...

C07C32700

Patent

active

051360764

ABSTRACT:
The (R) or (S) isomer of acetorphan or N-12-acetylthiomethyl-1-oxo-3-phenyl propyl/(S) alanine methyl ester is prepared by splitting of racemic 3-acetylthio-2-benzyl propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.

REFERENCES:
patent: 4798904 (1989-01-01), Delaney et al.

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