Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-05-13
1986-01-07
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548562, A61K 3140, C07D207327
Patent
active
045634777
ABSTRACT:
A process for the preparation of alpha-(N-pyrrolyl)-derivative acids, the salts and esters thereof, of the formula ##STR1## in which R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen atoms or substituted or unsubstituted alkyl, aryl, alkylaryl or heterocyclic radicals and R' is a metal cation, an organic base or an organic radical, wherein the corresponding amino ester is reacted with a dialkoxytetrahydrofuran or a derivative thereof. Certain compounds comprised among those corresponding to the above formula, particularly the DL, D and L-alpha-(N-pyrrolyl)-phenylacetic acids and certain esters thereof. Therapeutical compositions containing such compounds as active ingredient and therapeutical applications of said compounds.
REFERENCES:
Almmany Juarez I, Chem. Abs. 96, 217578 (Jun. 1, 1981).
Almmany Juarez II, Chem. Abs. 95, 42977r (1979).
Maldonado Francisco S.
Pla Luis C.
Puentes Jose L. F.
Sousa-Faro Jose M. F.
Antibioticos S.A.
Berch Mark L.
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