Process for the preparation of .alpha.-L-aspartyl-L-phenylalanin

Details Process for the preparation of .alpha.-L-aspartyl-L-phenylalanin Process for the preparation of .alpha.-L-aspartyl-L-phenylalanin

1973-11-05

1976-01-20

Brust, Joseph P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352, A23L 122

Patent

active

039337812

ABSTRACT:
A process for the preparation of .alpha.-L-aspartyl-L-phenylalanine alkyl esters wherein L-phenylalanine is reacted with N-protected-L-aspartic anhydride, the resulting product is treated to yield .alpha.-L-aspartyl-L-phenylalanine which is esterified with an alkanol to yield an .alpha.-L-aspartyl-L-phenylalanine alkyl ester which is recovered.
Novel precursors for .alpha.-L-aspartyl-L-phenylalanine alkyl esters are prepared in the process of this invention.

REFERENCES:
patent: 3769333 (1973-10-01), Lapidus et al.
patent: 3798204 (1974-03-01), Nakajima et al.
patent: 3798206 (1974-03-01), Uchiyama et al.
Mazur et al.: J. Am. Chem. Soc., 91, 2684-2691 (1969).
E. Schroder and K. Lubke, "The Peptides," Vol. I, pp. 52-53, Academic Press, New York (1965).
King et al.: J. Chem. Soc., 1949, 3315-3319.
Bodanszky and Ondetti, "Peptide Synthesis," Interscience, New York, 1966, p. 97.

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