Process for the preparation of .alpha.-bromo-phenylacetic acids

Details Process for the preparation of .alpha.-bromo-phenylacetic acids Process for the preparation of .alpha.-bromo-phenylacetic acids

1990-06-19

1991-07-30

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

546114, 562422, C07C 51093, C07C 5100

Patent

active

050361562

ABSTRACT:
Compounds of formula ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or halogen, are prepared by reacting an aldehyde of formula: ##STR2## with CHBr.sub.3 and KOH in a mixture of an inert solvent and water. Further an ester of compound (I) wherein R.sub.1 is H and R.sub.2 is 2-Cl is reacted with 4,5,6,7-tetrahydrothieno[3,2-c]pyridine to produce a compound of formula III: ##STR3## which is useful as a medicament.

REFERENCES:
Reeve et al., J. Org. Chem., vol. 45, pp. 5214-5215 (1980).

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