Process for the preparation of alpha-aryl-propionic acids and al

Details Process for the preparation of alpha-aryl-propionic acids and al Process for the preparation of alpha-aryl-propionic acids and al

1982-09-17

1985-08-20

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

549 66, 549 79, C07C 5110

Patent

active

045365954

ABSTRACT:
Alpha-arylpropionic acids and alkaline salts thereof are prepared by catalytic reaction with carbon monoxide of the corresponding secondary halids in an anhydrous low alcohol solvent in the presence of a salt of cobalt hydrocarbonyl and in further presence of alkaline hydroxides under substantially ambient temperature and pressure conditions.
The products obtained find useful applications in the field of pharmaceutics (analgesics, antipyretics, etc.) and as intermediates for chemical syntheses of fine chemicals, phytodrugs, etc.

REFERENCES:
patent: 3116306 (1963-12-01), Heck
patent: 3708529 (1973-01-01), Cassar
patent: 3928429 (1975-12-01), El-Chahawi
patent: 4111856 (1978-09-01), Haag
patent: 4152352 (1979-05-01), Perron
patent: 4351952 (1982-09-01), Foa

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