Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1993-09-08
1994-06-21
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
560 41, 560170, 564488, C07C20950
Patent
active
053229649
ABSTRACT:
There is disclosed a process for the preparation of an alpha-aminoketone salt of formula I ##STR1## which comprises reacting a nitrosated keto ester of formula II ##STR2## with a carboxylic anhydride of formula IV ##STR3## under the conditions of catalytic hydrogenation, to a compound of formula III ##STR4## which compound of formula III is then hydrolysed with an acid H.sub.n A to the salt I, in which formulae above R.sub.1 is C.sub.1 -C.sub.6 alkyl, phenoxy-C.sub.1 -C.sub.4 alkyl, phenyl, C.sub.7 -C.sub.9 phenylalkyl, or phenyl or C.sub.7 -C.sub.9 phenylalkyl which are substituted by halogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy, hydroxy or cyano, R.sub.2 is C.sub.1 -C.sub.4 alkyl or cyclohexyl, n is 1 to 3, R.sub.3 is C.sub.1 -C.sub.4 alkyl and A is the radical of an organic or mineral protic acid.
Pyrroles suitable as co-stabilisers for PVC can be prepared from alpha-aminoketone salts of formula I.
REFERENCES:
Ber. 35, 2998 (1902).
Chemistry and Industry (1971), 767.
Synthetic Communications 2(4), 237-242 (1972).
Chem. Pharm. Bull. 32(7), 2536-2543 (1984).
Ber. 44, 1542 (1911).
Heterocycles, vol. 29, No. 10, 1973-1982 (1989).
Drewes Rolf
Friedrich Hans-Helmut
Ciba-Geigy Corporation
Hall Luther A. R.
Raymond Richard L.
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