Process for the preparation of .alpha.-6-deoxytetracyclines

Details Process for the preparation of .alpha.-6-deoxytetracyclines Process for the preparation of .alpha.-6-deoxytetracyclines

1974-09-25

1976-06-08

Davis, C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10322

Patent

active

039623319

ABSTRACT:
This invention relates to a process for the preparation of .alpha.-6-deoxytetracyclines, by the simultaneous reductive dehalogenation and reduction by hydrogen, in a polar solvent of the corresponding 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline, in presence of a suitable member of the group of the tertiary phosphines, arsines and stibines, as regards the dehalogenation and of a catalyst, selected from amongst the complexes of noble metals with electron-donor ligands, soluble in the reaction medium, whereby the reaction is carried out according to the mechanism of the homogeneous catalysis.

REFERENCES:
patent: 3250809 (1966-05-01), Blackwood et al.
patent: 3649700 (1972-03-01), Baader et al.
patent: 3659006 (1972-04-01), Pande
Borowitz et al., JACS, 94:19, 9-20-72; 6817-6822.

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