Process for the preparation of .alpha.-6-deoxy-tetracyclines

Details Process for the preparation of .alpha.-6-deoxy-tetracyclines Process for the preparation of .alpha.-6-deoxy-tetracyclines

1984-08-17

1986-07-01

Hollrah, Glennon H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603511, C07C10319

Patent

active

045979049

ABSTRACT:
A process for the preparation of .alpha.-6-deoxy-tetracyclines by the stereoselective heterogeneous hydrogenation of a 6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, or the simultaneous dehalogenation and stereo-selective heterogeneous hydrogenation of an 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, characterized by the use of a rhodium salt catalysts, wherein the rhodium is bonded to a polysiloxane carrier, having the following formulae:

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Chemical Abstracts, vol. 86, 1977, p. 89476f.
British Pharmacopoeia 1980, vol. I, pp. 168-169.

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