Process for the preparation of .alpha.-[4-(4-chlorobenzoylaminoe

Details Process for the preparation of .alpha.-[4-(4-chlorobenzoylaminoe Process for the preparation of .alpha.-[4-(4-chlorobenzoylaminoe

1979-04-17

1983-01-25

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 9900

Patent

active

043704956

ABSTRACT:
A process for the preparation of 2-[4-(4-chlorobenzoylaminoethyl)-phenoxy]-2-methylpropionic acid of the formula ##STR1## which process comprises reacting N-(4-chlorobenzoyl)-tyramine with acetone and chloroform in a mole ratio of 1:20-100:2-10, in the presence of 3 to 4 moles of alkali per mole of chloroform, at a temperature of from about 10.degree. to 40.degree. C.

REFERENCES:
patent: 3781328 (1973-12-01), Witte et al.
patent: 3948973 (1976-04-01), Phillips
patent: 3970694 (1976-07-01), Minai et al.
Hebron, Chem. Abst., vol. 87, #134684f, (1977).
Mievillo, Chem. Abst., vol. 85, #192382a, (1976).

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