Process for the preparation of almotriptan

Details Process for the preparation of almotriptan Process for the preparation of almotriptan

2011-05-17

2011-05-17

Chu, Yong (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07943784

ABSTRACT:
The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl)1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydroxy benzoic acid yields hydroxy benzoic acid addition salt of Almotriptan iii) Converting Almotriptan hydroxy benzoic acid addition salt to Almotriptan and iv) Salification of Almotriptan to its pharmaceutically acceptable salts.

REFERENCES:
patent: 2084560 (1996-05-01), None
John A. Landgrebe, Theory and Practice in the Organic Laboratory, 4th edition, Chapter 6, p. 123-141, 1994.

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