Process for the preparation of alkyl 2-fluoro-isobutyrates

Details Process for the preparation of alkyl 2-fluoro-isobutyrates Process for the preparation of alkyl 2-fluoro-isobutyrates

1996-06-17

1998-03-03

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 6963

Patent

active

057236542

ABSTRACT:
Alkyl 2-fluoro-isobutyrates are prepared by reacting the corresponding sulphonic esters with potassium fluoride in an acid amide as solvent and in the presence of a base.

REFERENCES:
E. Fritz-Langhals, "Alkali Metal . . . Benzenes", Tetrahedron: Asymmetry, vol. 5, No. 6, pp. 981-986, 1994.
W.J. Gensler, et al., Fluorination of Methyl Isobutyrate with Perchloryl Fluoride.sup.1, J. Org. Chem., vol. 33, No. 11, pp. 4279-4281, (1968).
E. Fritz-Langhals, Alkali Metal Fluorides as Efficient Fluorinating Agents. Enantiocontrolled Synthesis of 2-Fluoroalkyl Carboxylates and 1-Fluoroalkyl Benzenes, Tetrahedron: Asymmetry, vol. 5, No. 6, pp. 981-986, (1994).

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