Process for the preparation of alkaline earth metal salts of (6R

Details Process for the preparation of alkaline earth metal salts of (6R Process for the preparation of alkaline earth metal salts of (6R

1992-10-02

1994-07-26

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544251, C07D47504

Patent

active

053328159

ABSTRACT:
A process for the preparation of alkaline earth metal salts of (6R)-N(10)-formyl-5,6,7,8-tetrahydrofolic acid. An alkaline earth metal salt, either in the form of a solid, or in the form of an aqueous solution, is added, preferably under an inert gas atmosphere, to an ammonium salt or alkali metal salt of (6RS)-N(10)-formyl-5,6,7,8-tetrahydrofolic acid dissolved in water or an aqueous buffer solution. II is added an alkaline earth metal salt either in the form of a solid or in the form of an aqueous solution. The obtained mixture is allowed to crystallize, and the obtained solid is separated. The product is known to be cytostatic.

REFERENCES:
patent: 4148999 (1979-04-01), Temple
patent: 5006655 (1991-04-01), Muller et al.
patent: 5010194 (1991-04-01), Muller et al.
patent: 5134235 (1992-07-01), Mueller et al.
patent: 5194611 (1993-03-01), Marazza et al.
patent: 5239074 (1993-08-01), Marazza et al.

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