Process for the preparation of alginate capsules, apparatus for

Details Process for the preparation of alginate capsules, apparatus for Process for the preparation of alginate capsules, apparatus for

1992-01-28

1993-04-20

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424401, 4241951, 424489, 424499, 428402, 514779, 514844, 514962, 536 3, A61K 700, A61K 948, A61K 31725

Patent

active

052041115

ABSTRACT:
A process for producing alginate capsules comprises slowly introducing an aqueous alginate solution into crosslinking solution of a polyvalent metal salt. The aqueous alginate solution has mannuronic units (M) and guluronic units (G) in a molar ratio between 0.4 and 1.9 and preferably an amount of (G) blocks greater than 50%. Preferably, the alginate is a sodium alginate having a viscosity, in a 0.5% solution in water at 25.degree. C., lower than 20 mPa.s measured with a TV Contraves viscosimeter having a No. 1 measurement body in the presence of a calcium chelate. The alginate concentration is between 0.2 and 2 weight percent. The polyvalent metal salt concentration in solution is from 3.4.times.10.sup.-3 to 6.8.times.10.sup.-2 M. The alginate capsules are employed in cosmetic compositions.

REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4692284 (1987-09-01), Braden
patent: 4701326 (1987-10-01), Nelsen et al.
patent: 4749620 (1988-06-01), Rha et al.
patent: 4765984 (1988-08-01), Vellekoop et al.
patent: 4806357 (1989-02-01), Garrett et al.
patent: 4923645 (1990-05-01), Tsang et al.
A. Kondo: "Microcapsule Processing and Technology", 1979 pp. 65-66, M. Dekker Inc., New York.

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