Process for the preparation of alginate capsules, apparatus for

Details Process for the preparation of alginate capsules, apparatus for Process for the preparation of alginate capsules, apparatus for

1990-04-09

1992-08-18

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

424 49, 424 59, 4241951, 424451, 424583, 424463, 424497, 512 1, 514779, 514844, 514962, 536 3, A61K 948, A61K 700

Patent

active

051397838

ABSTRACT:
A process for producing alginate capsules comprises slowly introducing an aqueous alginate solution into crosslinking solution of a polyvalent metal salt. The aqueous alginate solution has mannuronic units (M) and guluronic units (G) in a molar ratio between 0.4 and 1.9 and preferably an amount of (G) blocks greater than 50%. Preferably, the alginate is a sodium alginate having a viscosity, in a 0.5% solution in water at 25.degree. C. lower than 20 mPa.s measured with a TV Contraves viscosimeter having a No. 1 measurement body in the presence of a calcium chelate. The alginate concentration is between 0.2 and 2 weight percent. The polyvalent metal salt concentration in solution is from 3.4.times.10.sup.-3 to 6.8.times.10.sup.-2 M.
The alginate capsules are employed in cosmetic compositions.

REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4692284 (1987-09-01), Braden
patent: 4701326 (1987-10-01), Nelsen et al.
patent: 4749620 (1988-06-01), Rha et al.
patent: 4806357 (1989-02-01), Garrett et al.
A. Kondo: "Microcapsule Processing and Technology", 1979, pp. 65-66, M. Dekker Inc., New York.

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