Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Reexamination Certificate
2006-01-17
2006-01-17
Tate, Christopher (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
C530S311000, C530S324000, C530S344000, C530S824000, C530S825000, C530S397000
Reexamination Certificate
active
06987173
ABSTRACT:
A process for the preparation of biologically active somatotropin from inclusion bodies of a recombinant host cell containing an inactive form of said somatotropin protein comprises the steps of:(a) contacting the inclusion bodies with an aqueous alcohol solution at an alkaline pH to solubilize said protein; and(b) bringing the solubilized protein into contact with a mild oxidizing agent to refold and form intramolecular disulfide bonds between cysteine residues of said protein.
REFERENCES:
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Han Kyuboem
Lee Hong-Kyun
Lee Yong-Jun
Katten Muchin & Rosenman LLP
LG Chemical Limited
Tate Christopher
Teller Roy
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