Process for the preparation of acitretin

Details Process for the preparation of acitretin Process for the preparation of acitretin

2006-10-31

2006-10-31

Carr, Deborah D. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

C554S207000, C554S212000

Reexamination Certificate

active

07129365

ABSTRACT:
The present invention relates to a cost effective and industrially useful process for the preparation of substantially pure acitretin. More specifically, the present invention relates to the preparation of acitretin of high purity and yield.

REFERENCES:
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patent: 2001903 (1993-10-01), None
patent: WO 98/03480 (1998-01-01), None
patent: WO98/03480 (1998-01-01), None
von Milan Soukup et al., “46. New Approaches to Some Aromatic Retinoids”,Helvetica Chimica Acta, 72:370-376 (1989).
Makuh et al.,Zh. Org. Chem., 25(4):792-797 (1989) (See Notes).
Andriamialisoa et al., “A new stereoselective synthesis of Acitretin.”,Helvetica Chimica Acta., 85:2926-2929 (2002).
Aurell et al., “Trienediolates of Hexadienoic Acids in Synthesis. Addition to Unsaturated Ketones. A Convergent Approach to the Synthesis of Retinoic Acids.”,Tetrahedron, 51(13):3915-3928 (1995).

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