Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1986-05-09
1987-11-10
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
435253, 530825, C12N 120, A61K 3902, A61K 3910
Patent
active
047056860
ABSTRACT:
This invention discloses a process for preparing an acellular Bordetella pertussis vaccine by passing culture supernatants or cellular extracts of B. pertussis through a column containing an ion exchange resin. The eluate from the column is detoxified and can then be employed by conventional means as a vaccine. The vaccine so produced has reduced toxicity due to the removal of endotoxin.
REFERENCES:
patent: 3141824 (1964-07-01), Dahlstrom
patent: 3184394 (1965-05-01), Schmidtberger et al.
patent: 3897309 (1975-07-01), Grabner
patent: 4029766 (1977-06-01), Helting
patent: 4234570 (1980-11-01), Kanbayashi et al.
patent: 4429046 (1984-01-01), Lin et al.
patent: 4455297 (1984-06-01), Syukuda et al.
patent: 4606919 (1986-08-01), Stojkovic et al.
Chem-Abstracts, vol. 59, 1963, 11911a-b, Onoue et al.
Chem-Abstracts, vol. 72, 1970, 51001v, Nakase et al.
J. Bacteriol 82, 648-656, (1961), Onoue.
J. Bacteriol. 86, 648-655, (1963), Onoue.
Japan J. Microbiol. 13, 359-366, (1969), Nakase.
Scott Jane V.
Waggett Joseph F.
American Cyanamid
Raymond R. P.
Schain Howard E.
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