Coating processes – Medical or dental purpose product; parts; subcombinations;... – Implantable permanent prosthesis
Reexamination Certificate
2005-07-05
2005-07-05
Michener, Jennifer (Department: 1762)
Coating processes
Medical or dental purpose product; parts; subcombinations;...
Implantable permanent prosthesis
C427S002100, C427S002140, C427S372200, C427S002300, C427S244000, C427S407100, C427S409000
Reexamination Certificate
active
06913779
ABSTRACT:
The following description refers to a process for the impregnation of cross-linked polymers with an active ingredient. The process is based on the used of compressed fluids, in particular CO2, with antisolvent effect, and involves the steps of impregnating the polymer with an active ingredient solution, adding a compressed fluid until precipitation of the active ingredient caused by the compressed fluid antisolvent effect, removing the solvent and the compressed fluid. The process allows to obtain accelerated release pharmaceutical formulations that, compared with the formulations already known, contain larger quantities of amorphous or nanocrystalline active ingredient.
REFERENCES:
patent: 5128142 (1992-07-01), Mulligan et al.
patent: 5340614 (1994-08-01), Perman et al.
patent: 6214384 (2001-04-01), Pallado et al.
patent: 6627246 (2003-09-01), Mehta et al.
patent: 0 405 284 (1991-01-01), None
Benedetti, et al., “Communication to the Editor. Production of Micronic Particles of Biocompatible Polymer Using Supercritical Carbon Dioxide,”Biotechnology and Bioengineering, vol. 53, pp. 232-237 (1997).
Colombo Italo
Pallado Paolo
Eurand International S.p.A.
Michener Jennifer
Thompson Hine LLP
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