Process for the preparation of a triazolinone herbicide

Details Process for the preparation of a triazolinone herbicide Process for the preparation of a triazolinone herbicide

1998-10-14

2000-06-20

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D24912

Patent

active

060779594

ABSTRACT:
A process for preparing an alkyl .alpha.-2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4 -triazol-1-yl]-2,4-substituted-benzene-propanoate herbicide, by reacting an alkyl .alpha.-acetyl-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,4-t riazol-1-yl]-2,4-disubstituted-benzene-propanoate, Intermediate D, first with sodium hypochlorite, then with a base, and recovering the herbicide. Intermediate D is prepared by reacting a 1-(2, 4-disubstituted-5-halophenyl)-4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo- 1H-1,2,4-triazole, Intermediate B, with an alkyl alkanoate in the presence of a palladium catalyst and a tertiary amine. Intermediate B is prepared by reacting a 1-(2,4-disubstituted-phenyl)-4-difluoromethyl-4,5-dihydro-3-methyl-5-oxo-1 H-1,2,4-triazole with a halogenating agent in the presence of an acid. The 2,4-substituents are independently selected from halo, alkyl, cycloalkyl, alkoxy, nitro, or hetercyclyl.

REFERENCES:
patent: 5125958 (1992-06-01), Poss
patent: 5621112 (1997-04-01), Ager et al.
Theodoridis G: "Structure-Activity Relationships Of Herbicidal Aryltriazolinones", Pesticide Science, vol. 50, No. 4, Aug. 1997, pp. 283-290.

Affiliated with

Also associated with

Rating

Process for the preparation of a triazolinone herbicide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of a triazolinone herbicide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of a triazolinone herbicide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1854670