Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1981-02-10
1983-08-02
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
A61K 4904
Patent
active
043965970
ABSTRACT:
Sterile, injectable, physiologically acceptable solutions of an X-ray contrast agent are prepared by autoclaving a solution of a m-carboxamido-o-iodo-N-(.beta.-hydroxyalkyl)aniline X-ray contrast agent in the presence of a physiologically acceptable buffer system the pH of which decreases with increasing temperature.
The presence of a temperature dependent buffer, preferably an amine, enables X-ray contrast agents to be sterilized by autoclaving without significant decomposition.
Examples of the autoclaving processes are given and solutions for autoclaving containing a m-carboxamido-o-iodo-N-(.beta.-hydroxyalkyl)aniline X-ray contrast agent and a physiologically acceptable buffer system the pH of which decreases with increasing temperature are described and claimed.
REFERENCES:
patent: 3910989 (1975-10-01), Felder et al.
patent: 4021481 (1977-05-01), Almen et al.
patent: 4101647 (1978-07-01), Clauss et al.
patent: 4132731 (1979-01-01), Klieger et al.
patent: 4250113 (1981-02-01), Nordal et al.
patent: 4256729 (1981-03-01), Lin
Kelly Michael J.
Rakli Fridtjov B.
Nyegaard & Co. A/S
Waddell Frederick E.
LandOfFree
Process for the preparation of a sterile injectable physiologica does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of a sterile injectable physiologica, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of a sterile injectable physiologica will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-483676