Process for the preparation of a stable modification of torasemi

Details Process for the preparation of a stable modification of torasemi Process for the preparation of a stable modification of torasemi

1992-12-03

1994-04-05

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21370, C07D21374, A61K 3144

Patent

active

RE0345806

ABSTRACT:
The present invention provides a process for the preparation of crystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, [melting point 162.degree. C.)] in prism form) from torasemide of modification II (monoclinic, space group P2
, [melting point 169.degree..),] in leaflet form), wherein a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete.
The present invention also provides a pharmaceutical compositions containing stable torasemide of modification I.

REFERENCES:
patent: 4018929 (1977-04-01), Delarge et al.
Morrison et al., Org. Chem., 3rd Ed., pp. 127-128 (1973).
Condensed Chemical Dictionary, 10 Ed., p. 880 (1981).
Acta Cryst., (1978) pp. 2659-2662, 1304-1310.

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