Process for the preparation of a stable factor VIII

Details Process for the preparation of a stable factor VIII Process for the preparation of a stable factor VIII

1993-12-14

1995-06-13

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530381, 530415, 530416, C07K 118, C07K 14755

Patent

active

054244013

ABSTRACT:
A process for the preparation of a pasteurized factor VIII concentrate with high specific activity and stability is described, which comprises adsorbing impurities from the solution containing the factor VIII by at least two-fold adsorption with Al(OH).sub.3, an anion exchanger or Ca.sub.3 (PO.sub.4).sub.2, preferably with two different adsorbents from this group.

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Fay et al., "Purification And Characterization of a Highly Purified Human Factor VIII consisting of a Single Type of Polypeptide Chain," Proc. Nat'l. Acad. Sci, USA, vol. 79, pp. 7200-7204, Dec. 1982.
S. van Creveld et al., "The Separation of AHF from Fibrinogen," Thromb. Diathes, VI(2/3), pp. 282-286, 1961.
Baugh et al., "Separation of Human Factor VIII Activity from the Von Willebrand's Antigen and Ristocetin Platelet Aggregating Activity," Biochimica et Biophysica Acta, vol. 371, pp. 360-367, 1974.

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