Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-08-01
1991-12-24
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
424 858, C07K 328, C07K 1514, A61K 39395
Patent
active
050754254
ABSTRACT:
Process for the preparation of an immunoglobulin solution suitable for intravenous administration from a human blood protein fraction containing immunoglobulins IgG, IgA and IgM in partially concentrated from, with the process steps: addition of acetate buffer to the protein fraction, where appropriate removal of insoluble constituents by filtration, treatment with calcium phosphate and octanoic acid, centrifugation, removal of the supernatant and treatment thereof with an adsorbent, removal of the adsorbent and sterilization by filtration.
REFERENCES:
patent: 4318902 (1982-03-01), Stephan
Kotitschke Ronald
Moller Wolfgang
Piechaczek Detlef
Rudnick Dieter
Stephan Wolfgang
Biotest Pharma GmbH
Ekstrom Richard C.
Schain Howard E.
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